The McDevitt laboratory at New York University has a long tradition of developing new medical microdevice technologies that are suitable for early disease detection. In this general area, a MEGA grant sponsored by the NIDCR division of the NIH has been awarded recently with the goal of developing next generation cytomics-on-a-chip tools for oral cancer diagnosis. This multi-institution prospective cohort study seeks to utilize and optimize first Point-of-Care Oral Cytopathology Tool (POCOCT), a microfluidics ensemble and single cell image-based data acquisition system employing artificial intelligence with interpretation of >100 image features including nuclear F-actin for precision oral lesion diagnostics to be completed. Portable diagnostic tools and embedded algorithms will be optimi